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Your Position: Home > Papain-like Protease

Papain-like Protease

Brief Information

Name:SARS-CoV-2-3C-like-proteinase
Target Synonym:Papain-like proteinase,p65 homolog,MPro,3CL-PRO,GFL,Growth factor-like peptide,Leader protein,Non-structural protein 1,Non-structural protein 10,Non-structural protein 7,Non-structural protein 6,Non-structural protein 4,Non-structural protein 3,Non-structural protein 2,Non-structural protein 11,Non-structural protein 8,Non-structural protein 9,nsp1,nsp10,nsp11,nsp2,nsp3,nsp4,nsp5,nsp6,nsp7,nsp8,nsp9,ORF1a polyprotein,SARS coronavirus main proteinase,Replicase polyprotein 1a,pp1a,PL-PRO,PL2-PRO
Number of Launched Drugs:5
Number of Drugs in Clinical Trials:27
Lastest Research Phase:Approved

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Cat. No. Species Product Description Structure Purity Feature
PAE-C5148 SARS-CoV-2 SARS-CoV-2 (COVID-19) Papain-like Protease Protein, His Tag (active enzyme)
PAE-C5148-structure
PAE-C5148-sds
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Synonym Name

Papain-like Protease,Replicase polyprotein 1a,ORF1a polyprotein,pp1a,1a,PL-PRO,Plpro

Background

New coronavirus is a single-stranded RNA positive-strand envelope type B coronavirus. Similar to the other two coronaviruses that cause SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome), its genome encodes non-structural, structural, and accessory proteins. Non-structural proteins include 3-chymotrypsin-like protease (3CLpro), papain-like protease, helicase, and RNA-dependent RNA polymerase (RNA -dependent RNA polymerase (RdRp). Structural proteins include spike glycoproteins. Papain in coronavirus is the same as 3CLpro. This enzyme operates on no less than 11 cleavage sites on the large polyprotein 1ab. Processing of polyproteins translated from viral RNA is essential. Therefore, press this The activity of this enzyme will prevent virus imitation.

Clinical and Translational Updates

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